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This process leads to severe oxidative damage if left unchecked, compromising membrane integrity and ultimately triggering ferroptosis

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A key randomized trial conducted by the European Group for the Study of Graves Orbitopathy (EUGOGO) demonstrated that Se supplementation (200 g/day) reduced the severity of TED and improved quality of life in patients [80]

This has been shown to result in decreased production of pro-inflammatory cytokines such as Tumor Necrosis Factor alpha (TNF-), interleukin 6 (IL-6), interleukin 8 (IL-8), and interferon gamma (IFN-), and inflammation markers such as cyclooxygenase 2 (COX2) 26,45